-
by Samantha Cicero, PhD
Retinoblastoma is the third most common form of cancer in infants. Samantha Cicero, PhD, describes the consequences of inactivation of the p53 pathway in retinoblastoma. She begins by describing the demographics and characteristics of retinoblastoma and the landmark discoveries in retinoblastoma...
Keywords: Retinoblastoma, p54 Pathway, genetics, cancer genetics, gene inactivation, p53, p54, MDMX...
-
by Kyle M. Johnson, PhD
Kyle Johnson, PhD, presents recent advances in hematopoiesis that can be applied to future research focused on understanding specific problems related to the treatment of pathological conditions. He explains the hematopoietic process and its importance in healthy individuals. He then outlines the...
Keywords: hematopoiesis, cytokine, stem cell, stem cells, lymphoid cells, myeloid cells, Gata-2...
-
by Lisa Bouchier-Hayes, PhD
Lisa Bouchier-Hayes, PhD provides an excellent review of apoptosis, or programmed cell death, including the fundamental steps of apoptosis and its importance in cell function. The importance of apoptosis is to sculpt tissues in embryogenesis and metamorphosis, which are primary steps for growth...
Keywords: apoptosis, confocal microscopy, cytocrome, cytochrome c-GFP, homeostasis, fluorescent proteins
-
by Melanie Van Stry, PhD
Melanie Van Stry, PhD, presents a seminar on the epigenetic regulation of cytokine expression during T helper cell development. One of the definitions of epigenetics is how a cell remembers who it is. Epigenetic studies are important because 1) epigenetic gene regulations are necessary for embryo...
Keywords: epigenetics, epigenetic gene regulation, chromatin, histone, histone code, Mina53
-
by Jason Rosch, PhD
Currently available antibiotics target various mechanisms in bacterial pathogens; such mechanisms include cell wall synthesis, protein synthesis, DNA and RNA replication, and folate metabolism. However, bacteria have developed various means of resistance to these antibiotics. Therefore, there...
Keywords: antibiotic resistance, calcium transport, Streptococcus pneumoniae, antibiotic targets...
-
by Aaron M. Shafer, PhD
Aaron M. Shafer, PhD, describes the GMP facility at St. Jude Children’s Research Hospital. “GMP” refers to good manufacturing practices, and in this GMP facility, therapeutic agents are produced under strict guidelines of the U.S. Food and Drug Administration. During his...
Keywords: GMP, Good Manufacturing Practices, neuroblastoma, therapeutic antibodies, Cytotoxicity, Avian Flu...
-
by James R. Downing, MD
Keywords: Leukemia, Acute Lymphoblastic Leukemia, t(15;17), chromosome translocation, chromosome deletion...
|