|Science Sound Bites is an initiative of the Postdoctoral Leadership Council at St. Jude Children's Research Hospital. Geared to connect both in language and level of detail with secondary school STEM teachers and students, these casual interviews reinforce current science standards and provide much-needed examples of how scientific research applies in the real world.|
SSB 027: Tackling Antibiotic Resistance
In this episode of Science Sound Bites, Julian Hurdle, PhD discusses the importance of antibiotic resistance and how resistance genes can be transferred between bacteria. Hurdle will also tell us about how he settled into his professorship at Texas A&M and his lab’s efforts to find new antibiotics against Clostridium difficile infection.
Key Words: Plasmids, Soil bacteria, Clostridium difficile, Metronidazole, Selection pressure, Small molecule drugs
SSB 026: Channeling Darwin in the Lab
In this episode of Science Sound Bites, Sachdev Sidhu, PhD discusses the importance of proteins in directing the actions of the cell.
Key Words: Directed evolution, Bacteriophage, Synthetic Antibodies, Phage display, Commercialization
SSB 025: Fantastic Parasites and How to Kill Them
In this episode of Science Sound Bites, Lindsay Turnbull, PhD discusses the transmission of the malaria virus between mosquitos and humans.
Key Words: malaria, disease vector, field site, chloroquine, combination therapy, parasite, hemoglobin
SSB 024: Models aren't just for LEGOs anymore, kids
In this episode of Science Sound Bites, Jessica Rogers, PhD discusses how mathematical models help doctors personalize healthcare for pediatric patients.
Key Words: Pharmacology, Glucocorticoid, Genome, Mathematical Models, Mathematical Fit, Leukemia
SSB 023: Bonus Episode!
In this episode of Science Sound Bites, Meet your Co-hosts:
Dr. Nicole Milkovic, Department of Structural Biology
Dr. Raju Rayavarapu, Department of Cell and Molecular Biology
Dr. Dinesh Fernando, Department of Chemical Biology and Therapeutics
Dr. Peter Mercredi, Department of Structural Biology
SSB 022: No Barriers No Problem
In this episode of Science Sound Bites, Dr. Nicole Milkovic discusses proteins that function as the glue that holds biomolecules within the nucleolus.
Key Words: structural biology, macromolecules (DNA, RNA, proteins), organelles (membrane-bounded), membrane-less organelles, mitochondria, nucleus, nucleolus, ribosomes, nucleophosmin 1 (NPM1, NPM), multifunctionality, nucleoplasm, cytoplasm, ribosome biogenesis, cell division, tumour suppression, p53, cellular stress (starvation, thermal, UV radiation), phase separation (liquid to liquid), phase transition (solid, liquid, gas), physiochemical properties, transcription, ribosomal RNA, molecular interactions, electrostatic interactions, amino acids, disordered proteins, unfolded and folded proteins, N-terminus, pentimerization domain, pentapus, multivalency, solubilization, post-translational modifications, phosphorylation, enzyme.
SSB 021: Stay Curious
In this episode of Science Sound Bites, we say goodbye to our host, Michael Johnson, as he enters the next phase of his scientific adventures by starting his own lab at the University of Arizona Health Sciences. We also meet one of the new cohosts of Science Sound Bites, Dr. Nicole Milkovic.
Key Words: pharmacology, pharmacy, kinetics, microbiology, transferrable skills, structural biology, pili/pilus, beneficial metals, calcium, copper, ribonucleotide reductase, macrophages, flagella, nosocomial infections, antimicrobial, drug-drug interactions, organic chemistry, immunology, proteins, atoms, bacteria, cystic fibrosis, pH, Reactive oxygen species, oxidizing, free radicals, host cell, mechanisms, binding motifs, assay
SSB 020: Finding the Keys to Stop Zika Virus
In this episode of Science Sound Bites, Michael interviews the Dr. Husni Elbahesh from the Univerity of Tennessee Health Science Center to discuss viruses.
Key Words: Virus, DNA, Protein, Zika, Flavivirus, Dengue, Coding strand, RNA, Transcription, Translation
SSB 019: DN-"A" Team
In this episode of Science Sound Bites, Michael interviews the DN-"A" Team, the founders and developers of DNA Day and other educational and community outreach inititatives of the National Human Genome Research Institute.
Key Words: DNA, DNA Day, Teacher Resources, Genomics Education
SSB 018: Going Supersonic in Making Therapeutics
In this episode of Science Sound Bites, Michael interviews Dr. Wendy Pierce, Neurobiology and Brain Tumor Project Coordinator at St. Jude Children's Research Hospital to discuss protein pathways, different scientific careers, and facilitating the process of making therapeutics for brain tumors.
Key Words: Scientific Careers, Protein, Disorder, Cell Development, Crystallography, Medulloblastoma, Developmental Disorder, Drosophila, Chemical Biology, Bench to Bedside
SSB 017:Check Yo Genes Before You Wreck Yo Genes
In this episode of Science Sound Bites, Michael interviews Dr. Cristel Camacho, a postdoctoral fellow at St. Jude Children's Research Hospital. Cristel's research focuses on the tumorigenic impact of DNA repair deficiencies in the central nervous system.
Key Words: Genes, DNA Repair, Tumorigenic, Central Nervous System
SSB 016: MacGyvering Treatments for Infectious Diseases
In this episode of Science Sound Bites, Michael interviews Dr. Sheena Mukkada, a clinical fellow at St. Jude Children's Research Hospital. Mukkada's research focuses on the development and evaluation of resource appropriate tools for treating children with cancer in resource limited settings.
Key Words: Master's in Public Health (MPH), Research Design, Infectious Diseases, Resource Limited Settings, Cancer, White Blood Cells, Immunocompromised, Diagnostic Tools, Blood Cultures, Bacterial Diversity, Antibiotic Resistance, Virus Pneumonia, Aerobic
SSB 015: Cut the Cord and Keep It
In this episode of Science Sound Bites, Michael interviews Dr. Suzanne Tomchuck, a staff scientist at St. Jude Children's Research Hospital. Tomchuck's research focuses on the use of umbilical cord blood as an alternative transplant therapy for pediatric cancers and other blood disorders.
Key Words: Bone Marrow Transplant, Cord Blood Transplant, Blood Disorders, Cells, Cancer, Umbilical Cord Blood, Proteins, Immune System, Immuno-competent, Immuno-compromised, Engraftment, Chemotherapy, T Cells, Natural Killer Cells, Innate Immune Response, Stem Cells
SSB 014: Preventing a Total Eclipse of the Heart
In this episode of Science Sound Bites, Michael interviews Dr. Monique Anderson, Assistant Professor of Medicine in Cardiology at the Duke University School of Medicine and the Duke Clinical Research Institute. Anderson's research focuses on the quality of care for patients who require cardiac resuscitation.
Key Words: Cardiac Resuscitation, Quality of Care, Cardiology, Cardiac Arrest, Heart Rhythm, Warning Signs, Heart Attack, Coronary Artery, Arrhythmia
SSB 013: Don't Eat Me Bro
In this episode of Science Sound Bites, Michael interviews Dr. Esther Ngumbi, a post-doctoral fellow with the Entomology Department at Aubern University, Alabama. Ngumbi is a founder of several initiatives including OYESKA GREENS-a startup company aiming to revolutionize agriculture at the Kenyan Coast and Spring Break Kenyan organization that is galvanizing young Kenyan university students into public service.
Key Words: Symbiosis, Plants, Soil, Beneficial Microbes, Bacteria, Nutrition, Environment, Pesticides, Insects, Chemistry, Aroma, Discovery, Patent, Plant Decoy System, Natural Products, Bacillus subtillus, Spores, Crops
SSB 012: An Interview with the CEO of St. Jude Children's Research Hospital
In this episode of Science Sound Bites, Michael interviews Dr. James R. Downing, the President and CEO of St. Jude Children's Research Hospital. In honor of Childhood Cancer Awareness Month, Dr. Downing discusses St. Jude's role in finding cures for childhood cancers as well as other catestrophic diseases.
Key Words: Cancer, Genomics, Bioinformatics, DNA, Sickle cell, Lymphoma, Solid cell tumor, Metastatic cancer, Brain tumor, Physiology, Biopsy, Diseases of the blood, Hematophathology, Leukemia, Protein, Cells, Sequencing, Human genome project, Pediatric cancer genome project, Glioma, Therapeutic, Molecule, Mutation
SSB 011: Catching up with the Director of the National Institutes of Health
In this episode of Science Sound Bites, Michael interviews Dr. Francis Collins, the Director of the National Institutes of Health. Dr. Collins oversees the work of the largest supporter of biomedical research in the world, spanning the spectrum from basic to clinical research.
Key Words: Genome, Genes, National Institutes of Health, Brain Research, Infections, Bioinformatics, Genetics, DNA, Sequence, Scientific Grants, 1 Million Genomes, Cancer, Human Genome Project
SSB 010: Cells Got Rhythm, Who Could Ask For Anything More
In this episode of Science Sound Bites, Michael interviews Dr. Brandon Cox, a former postdoctoral fellow at St. Jude Children's Research Hospital. Dr. Cox researches hearing loss and hair cell regeneration.
Key Words: Hearing Damage, Frequency of Sound, Basal, Apical, Hair Cells, Ear, Cochlea, Reactive Oxygen Species, Mutation, Regeneration, Cell Proliferation, Electromotility, Amplify, Therapeutics, Cystic Fibrosis
SSB 009: Put Down the Brownie, It May Help You Fight Off the Flu
In this episode of Science Sound Bites, Michael interviews Dr. Erik Karlsson, a postdoctoral fellow at St. Jude Children's Research Hospital. Dr. Karlsson researches the impact of diet and nutrition on viral evolution and virulence factors.
Key Words: Obesity, Virus, Influenza, Nutrition, BMI, Infection, Cytokine, Inflammation, Bacteria, Immune System, Non-Communicable Diseases, Adipose Cells, Fever, Chronic Inflammatory State, Proteins, Pathogen, Immunocompromised
SSB 008: Dueling Bacteria
In this episode of Science Sound Bites, Michael interviews Dr. Peggy Cotter, a professor at the University of North Carolina Chapel Hill, where she researches various bacterial virulence factors.
Key Words: Microbiology, Bacteria, Virulence, Protein, Vaccine, Diagnostics, Whooping Cough, Proliferate, DNA, Bacterial Community, Rhizoshpere, Biofilm, Antibiotic, Microbiome, Flora, Cystic Fibrosis, Therapeutic
SSB 007: Don't Avoid Small Schools Like the Plague
In this episode of Science Sound Bites, Michael interviews Dr. Vijay Sivaraman, an assistant professor at North Carolina Central University. Vijay studies the bacteria responsible for the plague.
Key Words: HBCU Contributions, Respiratory Disease, Networking, Pneumonia, Disease, "The Plague", Infection, Attenuated, Cell Culture, Organism, Mutation, Immune Response, Pathogen, Inflammation, Protein, Virulence Factor, Immunopathology, Homology, Problem Solving, Cytokine
SSB 006: Keeping Bacteria Out of Line
In this episode of Science Sound Bites, Michael interviews Dr. Joshua Wolf, a pediatric infectious diseases doctor at St. Jude. In addition to his clinical duties treating infections in children who have cancer, Josh spends time in the lab researching methods for preventing and treating infections and improving patient outcomes.
Key Words: Antibacterial, Infectious diseases, Antibiotics, Antimicrobial, Medicine, Bacteria, Fungus, Virus, SEM, Antibiotic resistance, IV lines, Protein, Chemotherapy, Colonized, Cancer, Immune system, Control trial, Experiment, Research
SSB 005: Knocking Infections Off the Catwalk with Mathematical Models
In this episode of Science Sound Bites, Michael interviews Dr. Amber Smith, a mathematical biologist at St. Jude. Using applied mathematics, Amber investigates the dynamics of viral and bacterial infections.
Key Words: Math, Biology, Infectious Disease, Influenza, Secondary Bacterial Infection, Virus, Virus Spread, Ecology, Chemistry, Physics, Epidemiology, Probability, Cell, Populations, Vaccine, Math models
SSB 004: Mean, Green, Timekeeping, and Energy Making Machine
In this episode of Science Sound Bites, Michael interviews Dr. Beronda Montgomery, a biochemist at Michigan State University, where she researches how immobile organisms respond to changes in their environment.
Key Words: Plants, Photosynthesis, Protein, Electron, Energy, Light, Photon, Wavelength, Chromophore, DNA, Photoperiod, phytochrome, Solar power, Organism, Sunlight, Nutrient, Sugar, Cells, Environment, Public speaking, Writing
SSB 003: All Star Catcher for the Body
In this episode of Science Sound Bites, Michael interviews Dr. Delira F. Robbins, a postdoctoral fellow at St. Jude. Delira researches the role of nuclear receptors in various diseases.
Key Words: Drug, Drug Metabolism, Drug Modification, Solubility, Protein, DNA, Binding, Activation and Repression, Nucleus, Receptor, Genes, Molecule, Binding Pocket, Xenobiotic, Enzyme
SSB 002: Crystal Clear
In this episode of Science Sound Bites, Michael interviews Dr. Clifford Froelich, a postdoctoral fellow at St. Jude. Using x-ray crystallography, Clifford studies the molecular machinery involved in DNA replication, translation, and transcription.
Key Words: Crystallography, Protein, DNA, RNA, Dogma, Translation, Transcription, Postdoc, X-Ray, Atomic, DNA replication, Helicase, Replication, Binding, Drug, Drug Discovery, Cancer
SSB 001: Traffic on Cancer Avenue
In this episode of Science Sound Bites, Michael interviews Dr. Zach Faber, a postdoctoral fellow at St. Jude. Working on the Pediatric Cancer Genome Project, Zach researches DNA changes that lead to the development of leukemia.
For more information related to this interview, visit our Hallmarks of Cancer interactive.
Key Words: Hallmarks of Cancer, Pediatric Cancer Genome Project (PGCP), Leukemia, Gene, DNA, Sequencing, Nucleotide, RNA, Codon, Amino acid, Mutations, Protein, Transcription, Translation, Cell Cycle, Restriction Point