Podcast

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Science Sound Bites is an initiative of the Postdoctoral Leadership Council at St. Jude Children's Research Hospital. Geared to connect both in language and level of detail with secondary school STEM teachers and students, these casual interviews reinforce current science standards and provide much-needed examples of how scientific research applies in the real world.

SSB 031: Chaperoning Structural Biology

In this episode of Science Sound Bites, Dr. Kalodimos, the Chair of the St. Jude Structural Biology Department, talks about his new role in at St. Jude family and how Structural Biology can help identify new chemotherapies.

Key words:

Structural biology, Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI), Cryo-electron microscopy, Macromolecules, Molecular Chaperones, Kinase, Adenosine Triphosphate (ATP), Chronic Myelogenous Leukemia 

To facilitate the use of this podcast in your K-12 classroom, try using the student study guide

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SSB 030: You Make What You Eat

In this episode of Science Sound Bites, Dr. Joshua A. Mason, a newly minted Ph.D, now at the Palm Beach Atlantic University talks about how glucose, the sugar in the food we eat, helps make all the pieces that our cells need to survive and grow. Dr. Mason explains how glucose usage can be hijacked by cancer cells to help them grow better and faster than healthy cells.

To facilitate the use of this podcast in your K-12 classroom, try using the student study guide

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SSB 029: Our Hearts Go Buzz-Buzz

In this episode of Science Sound Bites, Dr. Isabelle King, a Physician Scientist at the University of California San Francisco, talks about how fruit flies, Drosophila melanogaster, can help us understand human heart development. Dr. King explains how things that regulate DNA called transcription factors can regulate the development and function of the heart.  

To facilitate the use of this podcast in your K-12 classroom, try using the student study guide

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SSB 028: What are You Wearing?

In this episode of Science Sound Bites, Michael Snyder, PhD discusses the use of wearable devices (such as FitBits and Smart Watches) in monitoring your own health. Snyder explains how he was able to use the information gathered from these so-called "wearables" in his own self-diagnosis of Lyme Disease, and how this information helped the doctors in Norway treat him correctly. 

Key Words: Puzzles, health, sequencing DNA, mass spectrometers, blood profile, measurements, microbes, biochemical picture, wearable devices (FitBit, smart watches, etc), heart rate, skin temperature, Lyme Disease, drug treatments, 23andme, individualized medicine, type 2 diabetes

To facilitate the use of this podcast in your K-12 classroom, try using the student study guide

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SSB 027: Tackling Antibiotic Resistance

In this episode of Science Sound Bites, Julian Hurdle, PhD discusses the importance of antibiotic resistance and how resistance genes can be transferred between bacteria. Hurdle will also tell us about how he settled into his professorship at Texas A&M and his lab’s efforts to find new antibiotics against Clostridium difficile infection.

Key Words: Plasmids, Soil bacteria, Clostridium difficile, Metronidazole, Selection pressure, Small molecule drugs

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SSB 026: Channeling Darwin in the Lab

In this episode of Science Sound Bites, Sachdev Sidhu, PhD discusses the importance of proteins in directing the actions of the cell.

Key Words: Directed evolution, Bacteriophage, Synthetic Antibodies, Phage display, Commercialization

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SSB 025: Fantastic Parasites and How to Kill Them

In this episode of Science Sound Bites, Lindsay Turnbull, PhD discusses the transmission of the malaria virus between mosquitos and humans.

Key Words: malaria, disease vector, field site, chloroquine, combination therapy, parasite, hemoglobin

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SSB 024: Models aren't just for LEGOs anymore, kids

In this episode of Science Sound Bites, Jessica Rogers, PhD discusses how mathematical models help doctors personalize healthcare for pediatric patients.

Key Words: Pharmacology, Glucocorticoid, Genome, Mathematical Models, Mathematical Fit, Leukemia

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SSB 023: Bonus Episode!

In this episode of Science Sound Bites, Meet your Co-hosts:

Dr. Nicole Milkovic, Department of Structural Biology

Dr. Raju Rayavarapu, Department of Cell and Molecular Biology

Dr. Dinesh Fernando, Department of Chemical Biology and Therapeutics

Dr. Peter Mercredi, Department of Structural Biology

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SSB 022: No Barriers No Problem

In this episode of Science Sound Bites, Dr. Nicole Milkovic discusses proteins that function as the glue that holds biomolecules within the nucleolus.

Key Words: structural biology, macromolecules (DNA, RNA, proteins), organelles (membrane-bounded), membrane-less organelles, mitochondria, nucleus, nucleolus, ribosomes, nucleophosmin 1 (NPM1, NPM), multifunctionality, nucleoplasm, cytoplasm, ribosome biogenesis, cell division, tumour suppression, p53, cellular stress (starvation, thermal, UV radiation), phase separation (liquid to liquid), phase transition (solid, liquid, gas), physiochemical properties, transcription, ribosomal RNA, molecular interactions, electrostatic interactions, amino acids, disordered proteins, unfolded and folded proteins, N-terminus, pentimerization domain, pentapus, multivalency, solubilization, post-translational modifications, phosphorylation, enzyme.

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SSB 021: Stay Curious

In this episode of Science Sound Bites, we say goodbye to our host, Michael Johnson, as he enters the next phase of his scientific adventures by starting his own lab at the University of Arizona Health Sciences. We also meet one of the new cohosts of Science Sound Bites, Dr. Nicole Milkovic.

Key Words: pharmacology, pharmacy, kinetics, microbiology, transferrable skills, structural biology, pili/pilus, beneficial metals, calcium, copper, ribonucleotide reductase, macrophages, flagella, nosocomial infections, antimicrobial, drug-drug interactions, organic chemistry, immunology, proteins, atoms, bacteria, cystic fibrosis, pH, Reactive oxygen species, oxidizing, free radicals, host cell, mechanisms, binding motifs, assay

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SSB 020: Finding the Keys to Stop Zika Virus

In this episode of Science Sound Bites, Michael interviews the Dr. Husni Elbahesh from the Univerity of Tennessee Health Science Center to discuss viruses.

Key Words: Virus, DNA, Protein, Zika, Flavivirus, Dengue, Coding strand, RNA, Transcription, Translation

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SSB 019: DN-"A" Team

In this episode of Science Sound Bites, Michael interviews the DN-"A" Team, the founders and developers of DNA Day and other educational and community outreach inititatives of the National Human Genome Research Institute.

Key Words: DNA, DNA Day, Teacher Resources, Genomics Education

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SSB 018: Going Supersonic in Making Therapeutics

In this episode of Science Sound Bites, Michael interviews Dr. Wendy Pierce, Neurobiology and Brain Tumor Project Coordinator at St. Jude Children's Research Hospital to discuss protein pathways, different scientific careers, and facilitating the process of making therapeutics for brain tumors.

Key Words: Scientific Careers, Protein, Disorder, Cell Development, Crystallography, Medulloblastoma, Developmental Disorder, Drosophila, Chemical Biology, Bench to Bedside

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SSB 017:Check Yo Genes Before You Wreck Yo Genes

In this episode of Science Sound Bites, Michael interviews Dr. Cristel Camacho, a postdoctoral fellow at St. Jude Children's Research Hospital. Cristel's research focuses on the tumorigenic impact of DNA repair deficiencies in the central nervous system.

Key Words: Genes, DNA Repair, Tumorigenic, Central Nervous System

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SSB 016: MacGyvering Treatments for Infectious Diseases

In this episode of Science Sound Bites, Michael interviews Dr. Sheena Mukkada, a clinical fellow at St. Jude Children's Research Hospital. Mukkada's research focuses on the development and evaluation of resource appropriate tools for treating children with cancer in resource limited settings.

Key Words: Master's in Public Health (MPH), Research Design, Infectious Diseases, Resource Limited Settings, Cancer, White Blood Cells, Immunocompromised, Diagnostic Tools, Blood Cultures, Bacterial Diversity, Antibiotic Resistance, Virus Pneumonia, Aerobic

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SSB 015: Cut the Cord and Keep It

In this episode of Science Sound Bites, Michael interviews Dr. Suzanne Tomchuck, a staff scientist at St. Jude Children's Research Hospital. Tomchuck's research focuses on the use of umbilical cord blood as an alternative transplant therapy for pediatric cancers and other blood disorders.

Key Words: Bone Marrow Transplant, Cord Blood Transplant, Blood Disorders, Cells, Cancer, Umbilical Cord Blood, Proteins, Immune System, Immuno-competent, Immuno-compromised, Engraftment, Chemotherapy, T Cells, Natural Killer Cells, Innate Immune Response, Stem Cells

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SSB 014: Preventing a Total Eclipse of the Heart

In this episode of Science Sound Bites, Michael interviews Dr. Monique Anderson, Assistant Professor of Medicine in Cardiology at the Duke University School of Medicine and the Duke Clinical Research Institute. Anderson's research focuses on the quality of care for patients who require cardiac resuscitation.

Key Words: Cardiac Resuscitation, Quality of Care, Cardiology, Cardiac Arrest, Heart Rhythm, Warning Signs, Heart Attack, Coronary Artery, Arrhythmia

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SSB 013: Don't Eat Me Bro

In this episode of Science Sound Bites, Michael interviews Dr. Esther Ngumbi, a post-doctoral fellow with the Entomology Department at Aubern University, Alabama. Ngumbi is a founder of several initiatives including OYESKA GREENS-a startup company aiming to revolutionize agriculture at the Kenyan Coast and Spring Break Kenyan organization that is galvanizing young Kenyan university students into public service.

Key Words: Symbiosis, Plants, Soil, Beneficial Microbes, Bacteria, Nutrition, Environment, Pesticides, Insects, Chemistry, Aroma, Discovery, Patent, Plant Decoy System, Natural Products, Bacillus subtillus, Spores, Crops

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SSB 012: An Interview with the CEO of St. Jude Children's Research Hospital

In this episode of Science Sound Bites, Michael interviews Dr. James R. Downing, the President and CEO of St. Jude Children's Research Hospital. In honor of Childhood Cancer Awareness Month, Dr. Downing discusses St. Jude's role in finding cures for childhood cancers as well as other catestrophic diseases.

Key Words: Cancer, Genomics, Bioinformatics, DNA, Sickle cell, Lymphoma, Solid cell tumor, Metastatic cancer, Brain tumor, Physiology, Biopsy, Diseases of the blood, Hematophathology, Leukemia, Protein, Cells, Sequencing, Human genome project, Pediatric cancer genome project, Glioma, Therapeutic, Molecule, Mutation

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SSB 011: Catching up with the Director of the National Institutes of Health

In this episode of Science Sound Bites, Michael interviews Dr. Francis Collins, the Director of the National Institutes of Health. Dr. Collins oversees the work of the largest supporter of biomedical research in the world, spanning the spectrum from basic to clinical research.

Key Words: Genome, Genes, National Institutes of Health, Brain Research, Infections, Bioinformatics, Genetics, DNA, Sequence, Scientific Grants, 1 Million Genomes, Cancer, Human Genome Project

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SSB 010: Cells Got Rhythm, Who Could Ask For Anything More

In this episode of Science Sound Bites, Michael interviews Dr. Brandon Cox, a former postdoctoral fellow at St. Jude Children's Research Hospital. Dr. Cox researches hearing loss and hair cell regeneration.

Key Words: Hearing Damage, Frequency of Sound, Basal, Apical, Hair Cells, Ear, Cochlea, Reactive Oxygen Species, Mutation, Regeneration, Cell Proliferation, Electromotility, Amplify, Therapeutics, Cystic Fibrosis

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SSB 009: Put Down the Brownie, It May Help You Fight Off the Flu

In this episode of Science Sound Bites, Michael interviews Dr. Erik Karlsson, a postdoctoral fellow at St. Jude Children's Research Hospital. Dr. Karlsson researches the impact of diet and nutrition on viral evolution and virulence factors.

Key Words: Obesity, Virus, Influenza, Nutrition, BMI, Infection, Cytokine, Inflammation, Bacteria, Immune System, Non-Communicable Diseases, Adipose Cells, Fever, Chronic Inflammatory State, Proteins, Pathogen, Immunocompromised

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SSB 008: Dueling Bacteria

In this episode of Science Sound Bites, Michael interviews Dr. Peggy Cotter, a professor at the University of North Carolina Chapel Hill, where she researches various bacterial virulence factors.

Key Words: Microbiology, Bacteria, Virulence, Protein, Vaccine, Diagnostics, Whooping Cough, Proliferate, DNA, Bacterial Community, Rhizoshpere, Biofilm, Antibiotic, Microbiome, Flora, Cystic Fibrosis, Therapeutic

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SSB 007: Don't Avoid Small Schools Like the Plague

In this episode of Science Sound Bites, Michael interviews Dr. Vijay Sivaraman, an assistant professor at North Carolina Central University. Vijay studies the bacteria responsible for the plague.

Key Words: HBCU Contributions, Respiratory Disease, Networking, Pneumonia, Disease, "The Plague", Infection, Attenuated, Cell Culture, Organism, Mutation, Immune Response, Pathogen, Inflammation, Protein, Virulence Factor, Immunopathology, Homology, Problem Solving, Cytokine

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SSB 006: Keeping Bacteria Out of Line

In this episode of Science Sound Bites, Michael interviews Dr. Joshua Wolf, a pediatric infectious diseases doctor at St. Jude. In addition to his clinical duties treating infections in children who have cancer, Josh spends time in the lab researching methods for preventing and treating infections and improving patient outcomes.

Key Words: Antibacterial, Infectious diseases, Antibiotics, Antimicrobial, Medicine, Bacteria, Fungus, Virus, SEM, Antibiotic resistance, IV lines, Protein, Chemotherapy, Colonized, Cancer, Immune system, Control trial, Experiment, Research

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SSB 005: Knocking Infections Off the Catwalk with Mathematical Models

In this episode of Science Sound Bites, Michael interviews Dr. Amber Smith, a mathematical biologist at St. Jude. Using applied mathematics, Amber investigates the dynamics of viral and bacterial infections.

Key Words: Math, Biology, Infectious Disease, Influenza, Secondary Bacterial Infection, Virus, Virus Spread, Ecology, Chemistry, Physics, Epidemiology, Probability, Cell, Populations, Vaccine, Math models

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SSB 004: Mean, Green, Timekeeping, and Energy Making Machine

In this episode of Science Sound Bites, Michael interviews Dr. Beronda Montgomery, a biochemist at Michigan State University, where she researches how immobile organisms respond to changes in their environment.

Key Words: Plants, Photosynthesis, Protein, Electron, Energy, Light, Photon, Wavelength, Chromophore, DNA, Photoperiod, phytochrome, Solar power, Organism, Sunlight, Nutrient, Sugar, Cells, Environment, Public speaking, Writing

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SSB 003: All Star Catcher for the Body

In this episode of Science Sound Bites, Michael interviews Dr. Delira F. Robbins, a postdoctoral fellow at St. Jude. Delira researches the role of nuclear receptors in various diseases.

Key Words: Drug, Drug Metabolism, Drug Modification, Solubility, Protein, DNA, Binding, Activation and Repression, Nucleus, Receptor, Genes, Molecule, Binding Pocket, Xenobiotic, Enzyme

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SSB 002: Crystal Clear

In this episode of Science Sound Bites, Michael interviews Dr. Clifford Froelich, a postdoctoral fellow at St. Jude. Using x-ray crystallography, Clifford studies the molecular machinery involved in DNA replication, translation, and transcription.

Key Words: Crystallography, Protein, DNA, RNA, Dogma, Translation, Transcription, Postdoc, X-Ray, Atomic, DNA replication, Helicase, Replication, Binding, Drug, Drug Discovery, Cancer

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SSB 001: Traffic on Cancer Avenue

In this episode of Science Sound Bites, Michael interviews Dr. Zach Faber, a postdoctoral fellow at St. Jude. Working on the Pediatric Cancer Genome Project, Zach researches DNA changes that lead to the development of leukemia.

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For more information related to this interview, visit our Hallmarks of Cancer interactive.

Key Words: Hallmarks of Cancer, Pediatric Cancer Genome Project (PGCP), Leukemia, Gene, DNA, Sequencing, Nucleotide, RNA, Codon, Amino acid, Mutations, Protein, Transcription, Translation, Cell Cycle, Restriction Point