Pharmacogenomics and Personalized Healthcare

This loan kit includes a problem-based learning case and hands-on modeling kit designed to teach students about the signs and symptoms of acute lymphoblastic leukemia (ALL) and methods for diagnosing and treating this disease. In addition, students consider the value of personalized healthcare and the relative risks associated with it. Students read through a fictional scenario in which a young girl is diagnosed with ALL. This case study is written for a middle school or high school biology course to reinforce the concepts of cell differentiation, genetics, and medicines. 

 

Learning Objectives

In this lesson, students will:

  • Define cancer, specifically acute lymphoblastic leukemia (ALL); 
  • Describe signs and symptoms of ALL; 
  • Compare and contrast normal and ALL blood samples;
  • Analyze the relationship between two variables and illustrate the relationship graphically;
  • Model 6-MP disruption of DNA replication; and
  • Consider the pros and cons of personalized healthcare

 

Materials

The Case of the Ballerina's Bump (student handout / clicker case)

3D Molecular Design DNA Replication Modeling Kit

3D Animation of DNA Replication

 

Time Required

2 x 45 minute class periods

 

Pacing Guide

Day 1

5-7 minutes

The Case of the Ballerina’s Bump: Part 1

5-7 minutes

The Case of the Ballerina’s Bump: Part 2

5-7 minutes

The Case of the Ballerina’s Bump: Part 3

25 minutes

Modeling DNA Replication

 

Day 2

5-7 minutes

The Case of the Ballerina’s Bump: Part 4

15 minutes

Modeling 6-MP Disruption of DNA Replication

5-7 minutes

The Case of the Ballerina’s Bump: Part 5

10 minutes

Modeling TPMT Activity

5 minutes

Exit Questions

 

*Used with permission from the Howard Hughes Medical Institute, Copyright (2003).  All rights reserved. www.BioInteractive.org.